Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

FG Teixeira, MM Carvalho, N Sousa… - Cellular and Molecular …, 2013 - Springer
The low regeneration potential of the central nervous system (CNS) represents a challenge
for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have …

[HTML][HTML] Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions

CM Walsh, JK Wychowaniec, DF Brougham… - Pharmacology & …, 2022 - Elsevier
Spinal cord injury (SCI) is a complex medical and psychological challenge for which there is
no curative therapy currently available. Despite major progress in pharmacological and …

[HTML][HTML] Cellular and subcellular oxidative stress parameters following severe spinal cord injury

NP Visavadiya, SP Patel, JL VanRooyen, PG Sullivan… - Redox biology, 2016 - Elsevier
The present study undertook a comprehensive assessment of the acute biochemical
oxidative stress parameters in both cellular and, notably, mitochondrial isolates following …

Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases

EC Simmons, NE Scholpa, RG Schnellmann - Experimental neurology, 2020 - Elsevier
Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Hydrogels in spinal cord injury repair: A review

Z Lv, C Dong, T Zhang, S Zhang - Frontiers in bioengineering and …, 2022 - frontiersin.org
Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI
is characterized by high disability and tends to occur among the young, seriously affecting …

Biomaterials for local, controlled drug delivery to the injured spinal cord

AM Ziemba, RJ Gilbert - Frontiers in pharmacology, 2017 - frontiersin.org
Affecting approximately 17,000 new people each year, spinal cord injury (SCI) is a
devastating injury that leads to permanent paraplegia or tetraplegia. Current …

Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

S Xu, W Zhu, M Shao, F Zhang, J Guo, H Xu… - Journal of …, 2018 - Springer
Background Immune activation, specifically activation of macrophages and resident
microglia, leading to inflammation is a key component in the progression of spinal cord …

Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury

NK Liu, LX Deng, M Wang, QB Lu, C Wang, X Wu… - Cell Death & …, 2022 - nature.com
Alterations in phospholipids have long been associated with spinal cord injury (SCI).
However, their specific roles and signaling cascades in mediating cell death and tissue …

Application of injectable hydrogels as delivery Systems in Spinal Cord Injury

R Ji, Z Hao, H Wang, X Li, L Duan, F Guan, S Ma - Gels, 2023 - mdpi.com
Spinal cord injury (SCI) is a severe neurological injury caused by traffic accidents, trauma, or
falls, which leads to significant loss of sensory, motor, and autonomous functions and …