Insect Transcription Factors: A Landscape of Their Structures and Biological Functions in Drosophila and beyond

Z Guo, J Qin, X Zhou, Y Zhang - International journal of molecular …, 2018 - mdpi.com
Transcription factors (TFs) play essential roles in the transcriptional regulation of functional
genes, and are involved in diverse physiological processes in living organisms. The fruit fly …

Hypoxia-tropic protein nanocages for modulation of tumor-and chemotherapy-associated hypoxia

X Huang, J Zhuang, SW Chung, B Huang, G Halpert… - Acs Nano, 2018 - ACS Publications
Despite its central role in tumor progression and treatment resistance, poor vascularization
that necessitates penetration of therapeutics through tumor extracellular matrix (ECM) …

E-cadherin roles in animal biology: A perspective on thyroid hormone-influence

MF Izaguirre, VH Casco - Cell Communication and Signaling, 2016 - Springer
The establishment, remodeling and maintenance of tissular architecture during animal
development, and even across juvenile to adult life, are deeply regulated by a delicate …

[HTML][HTML] TF-COMB–Discovering grammar of transcription factor binding sites

M Bentsen, V Heger, H Schultheis, C Kuenne… - Computational and …, 2022 - Elsevier
Cooperativity between transcription factors is important to regulate target gene expression.
In particular, the binding grammar of TFs in relation to each other, as well as in the context of …

A novel slug-containing negative-feedback loop regulates SCF/c-Kit-mediated hematopoietic stem cell self-renewal

Z Zhang, P Zhu, Y Zhou, Y Sheng, Y Hong, D Xiang… - Leukemia, 2017 - nature.com
The stem cell factor (SCF)/c-Kit pathway has crucial roles in controlling hematopoietic stem
cell (HSC) renewal. However, little is known about the intracellular regulation of the SCF/c …

The evaluation of transcription factor binding site prediction tools in human and Arabidopsis genomes

DV Wanniarachchi, S Viswakula… - BMC bioinformatics, 2024 - Springer
The precise prediction of transcription factor binding sites (TFBSs) is pivotal for unraveling
the gene regulatory networks underlying biological processes. While numerous tools have …

The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex

RM Carr, PAR Duran, EJ Tolosa, C Ma… - Journal of Biological …, 2020 - ASBMB
The expression of the extracellular sulfatase SULF2 has been associated with increased
hepatocellular carcinoma (HCC) growth and poor patient survival. However, the molecular …

Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma

L Tian, L Zhao, KMF Sze, CS Kam, VSI Ming… - Hepatology, 2022 - journals.lww.com
Conclusions Our results provide biological insight that dysregulation of RalA signaling
through dual regulatory mechanisms supports its oncogenic functions in HCC. Targeting …

S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity

M Muñoz-Bernart, N Budnik, A Castro, M Manzi… - Biology direct, 2023 - Springer
Background Lung cancer is one of the most frequently diagnosed cancers characterized by
high mortality, metastatic potential, and recurrence. Deregulated gene expression of lung …

Rewiring of the transcription factor network in acute myeloid leukemia

SA Assi, C Bonifer, PN Cockerill - Cancer Informatics, 2019 - journals.sagepub.com
Acute myeloid leukemia (AML) is a highly heterogeneous cancer associated with different
patterns of gene expression determined by the nature of their DNA mutations. These …