Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Neurodegenerative diseases (NDDs) are identified by the progressive deterioration of
neurons and a subsequent decline in cognitive function, creating an enormous burden on …

The main goal of this study was to evaluate the effects of arbutin (AR) on lipopolysaccharide
(LPS)-induced lung injury. A lung injury rat model was established by intravenous LPS …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …

Tolerance occurs when, following an initial experience with a substance, more of the
substance is required subsequently to induce identical behavioral effects. Tolerance is not …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced
by ethanol intake, and yet its molecular and circuit bases remain largely unexplored. Here …

Emotional disorders are common comorbid conditions that further exacerbate the severity
and chronicity of chronic pain. However, individuals show considerable vulnerability to the …

Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …