Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or
intramolecularly to form four stranded or “quadruplex” structures, which have unusual …

The urokinase plasminogen activator (uPA) system consists of the serine protease uPA, its
glycolipid-anchored receptor, uPAR and its 2 serpin inhibitors, plasminogen activator …

Background Nucleolin is one of the major proteins of the nucleolus, but it is also expressed
on the cell surface where is serves as a binding protein for variety of ligands implicated in …

AGRO100, also known as AS1411, is an experimental anticancer drug that recently entered
human clinical trials. It is a member of a novel class of antiproliferative agents known as G …

More than 46 years ago, Burnett and Kennedy first described protein kinase CK2 (formerly
known as casein kinase 2) in liver extracts. Since then, protein kinase CK2 has been …

Angiogenesis is known as one of the hallmarks in cancer which could play a key role in
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …

Nucleolin is a RNA-and protein-binding multifunctional protein. Mainly characterized as a
nucleolar protein, nucleolin is continuously expressed on the surface of different types of …

The discovery of G-rich oligonucleotides (GROs) that have non-antisense antiproliferative
activity against a number of cancer cell lines has been recently described. This biological …