Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

The potential of a spheroid tumor model composed of cells in different proliferative and
metabolic states for the development of new anticancer strategies has been amply …

A systematic combination strategy is proposed for overcoming cisplatin resistance using
near‐infrared (NIR)‐light‐triggered hyperthermia. A new photothermal polymer DAP‐F is …

Abstract Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three
dimensional (3D) architecture and complexity of human tumors. More representative models …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

A recent decline in the discovery of novel medications challenges the widespread use of 2D
monolayer cell assays in the drug discovery process. As a result, the need for more …

Cancer drug screening in patient‐derived cells holds great promise for personalized
oncology and drug discovery but lacks standardization. Whether cells are cultured as …

Despite untiring efforts to develop therapies for pancreatic ductal adenocarcinoma (PDAC),
survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming …

Introduction: Despite the increasing financial outlay on cancer research and drug discovery,
many advanced cancers remain incurable. One possible strategy for increasing the approval …