β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates
M Mora-Ochomogo, CT Lohans - RSC Medicinal Chemistry, 2021 - pubs.rsc.org
The β-lactams are the most widely used antibacterial agents worldwide. These antibiotics, a
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …
LD‐transpeptidases: the great unknown among the peptidoglycan cross‐linkers
A Aliashkevich, F Cava - The FEBS journal, 2022 - Wiley Online Library
The peptidoglycan (PG) cell wall is an essential polymer for the shape and viability of
bacteria. Its protective role is in great part provided by its mesh‐like character. Therefore, PG …
bacteria. Its protective role is in great part provided by its mesh‐like character. Therefore, PG …
The l,d-Transpeptidase LdtAb from Acinetobacter baumannii Is Poorly Inhibited by Carbapenems and Has a Unique Structural Architecture
l, d-Transpeptidases (LDTs) are enzymes that catalyze reactions essential for biogenesis of
the bacterial cell wall, including formation of 3–3 cross-linked peptidoglycan. Unlike the …
the bacterial cell wall, including formation of 3–3 cross-linked peptidoglycan. Unlike the …
A hierarchical approach towards identification of novel inhibitors against L, D-transpeptidase YcbB as an anti-bacterial therapeutic target
AS Alawam, L M. Alneghery… - Journal of …, 2024 - Taylor & Francis
The bacterial cell wall, being a vital component for cell viability, is regarded as a promising
drug target. The L, D-Transpeptidase YcbB enzyme has been implicated for a significant role …
drug target. The L, D-Transpeptidase YcbB enzyme has been implicated for a significant role …
Lactic acid bacteria secreted proteins as potential Listeria monocytogenes quorum sensing inhibitors
Listeria monocytogenes is an important human and animal pathogen able to cause an
infection named listeriosis and is mainly transmitted through contaminated food. Among its …
infection named listeriosis and is mainly transmitted through contaminated food. Among its …
EVOLUTION, FUNCTION, AND INHIBITION OF L, D TRANSPEPTIDASE ENZYMES OF MYCOBACTERIA
TA Zandi - 2022 - jscholarship.library.jhu.edu
The peptidoglycan layer of the bacterial cell wall is nearly universally conserved. It serves as
a protective barrier during the high turgor pressure encountered by a unicellular organism in …
a protective barrier during the high turgor pressure encountered by a unicellular organism in …