Sertoli cells for cell transplantation: pre‐clinical studies and future perspectives

G Luca, I Arato, G Sorci, DF Cameron, BC Hansen… - …, 2018 - Wiley Online Library
Sertoli cells are located in the testes where they control several key functions in
spermatogenesis. Over the past 30 years, Sertoli cells have been upgraded from a simple …

Targeting RAGE as a potential therapeutic approach to Duchenne muscular dystrophy

R Sagheddu, S Chiappalupi, L Salvadori… - Human Molecular …, 2018 - academic.oup.com
Duchenne muscular dystrophy (DMD) is a lethal X-linked disease affecting striated muscles,
which undergo progressive degeneration and chronic inflammation. Receptor for advanced …

Do porcine Sertoli cells represent an opportunity for Duchenne muscular dystrophy?

S Chiappalupi, L Salvadori, G Luca, F Riuzzi… - Cell …, 2019 - Wiley Online Library
Sertoli cells (SeC) are responsible for the immunoprivileged status of the testis thanks to
which allogeneic or xenogeneic engraftments can survive without pharmacological immune …

[HTML][HTML] Translational research on Myology & Mobility Medicine: 2021 semi-virtual PDM3 from Thermae of Euganean Hills, May 26-29, 2021

U Carraro, Z Yablonka-Reuveni - European Journal of …, 2021 - ncbi.nlm.nih.gov
Abstract On 19-21 November 2020, the meeting of the 30 years of the Padova Muscle Days
was virtually held while the SARS-CoV-2 epidemic was hitting the world after a seemingly …

Immunomodulatory role of Xenopus tropicalis immature Sertoli cells in tadpole muscle regeneration via macrophage response modulation

Q Zhao, I Mertová, A Wróblová, S Žabková… - Stem Cell Research & …, 2024 - Springer
Background Regenerative medicine and transplantation science continuously seek methods
to circumvent immune-mediated rejection and promote tissue regeneration. Sertoli cells …

Intraperitoneal injection of microencapsulated Sertoli cells restores muscle morphology and performance in dystrophic mice

S Chiappalupi, G Luca, F Mancuso, L Madaro… - Biomaterials, 2016 - Elsevier
Duchenne muscular dystrophy (DMD) is a genetic disease characterized by progressive
muscle degeneration leading to impaired locomotion, respiratory failure and premature …

Sertoli cells improve myogenic differentiation, reduce fibrogenic markers, and induce utrophin expression in human DMD myoblasts

L Salvadori, S Chiappalupi, I Arato, F Mancuso… - Biomolecules, 2021 - mdpi.com
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in DMD
gene translating in lack of functional dystrophin and resulting in susceptibility of myofibers to …

Employment of microencapsulated sertoli cells as a new tool to treat duchenne muscular dystrophy

S Chiappalupi, L Salvadori, G Luca, F Riuzzi… - Journal of Functional …, 2017 - mdpi.com
Duchenne muscular dystrophy (DMD) is a lethal X-linked pathology due to lack of dystrophin
and characterized by progressive muscle degeneration, impaired locomotion and premature …

[HTML][HTML] Microencapsulated Sertoli cells sustain myoblast proliferation without affecting the myogenic potential. In vitro data

S Chiappalupi, L Salvadori, F Mancuso, I Arato… - Data in Brief, 2022 - Elsevier
Sertoli cells (SeC) isolated from porcine testes have shown direct effects on muscle
precursor cells sustaining C2C12 myoblasts proliferation and inhibiting oxidative stress and …

Sertoli cells have promyogenic and antifibrotic effects, and induce utrophin expression in human DMD myotubes with different mutations in a heregulin β1/ErbB2 …

S Chiappalupi, L Salvadoi, I Arato… - Italian Journal of …, 2021 - search.proquest.com
Sertoli cells (SeC) are the major component of the seminiferous tubules, where they secrete
a plethora of trophic and immunomodulatory factors necessary to development of germ cells …