Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …

Enzymes fold into unique three-dimensional structures, which underlie their remarkable
catalytic properties. The requirement to adopt a stable, folded conformation is likely to …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

During the billions of years of the evolutionary journey, primitive polymers, involved in proto
metabolic pathways with low catalytic activity, played critical roles in the emergence of …

Self-assembly of molecules often results in new emerging properties. Even very short
peptides can self-assemble into structures with a variety of physical and structural …

Enzymatic activity is crucial for various technological applications, yet the complex structures
and limited stability of enzymes often hinder their use. Hence, de novo design of robust …

Highly sophisticated mechanisms that modulate protein structure and function, which involve
synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in …

In diverse natural enzyme systems, their elegant properties and functions appeal to great
interest not only in unraveling the natural profound mystery but also in engineering the …