The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Nanomedicine constitutes the emerging field of medical applications for nanotechnology
such as nanomaterial-based drug delivery systems. This technology may hold exceptional …

Background & aims In advanced chronic liver disease (ACLD), deregulated hepatic
necroinflammatory processes play a key role in the development of liver microvascular …

Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins.
We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and …

Background Many patients with primary biliary cholangitis have an inadequate response to
first-line therapy with ursodeoxycholic acid. Seladelpar is a potent, selective agonist for the …

Transcriptome profiling followed by differential gene expression analysis often leads to lists
of genes that are hard to analyze and interpret. Functional genomics tools are powerful …

Non‐alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome, being a common comorbidity of type 2 diabetes and with important links to …

Hepatic fibrosis is a major cause of morbidity and mortality worldwide, as it ultimately leads
to cirrhosis, which is estimated to affect up to 2% of the global population. Hepatic fibrosis is …

Patients with advanced liver cirrhosis may develop a clinical syndrome characterized by a
blunted contractile responsiveness to stress and/or altered diastolic relaxation, called …

Liver cirrhosis is a form of liver fibrosis resulting from chronic hepatitis caused by various
liver diseases, such as viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis …