Regulation of microtubule dynamics, mechanics and function through the growing tip

NB Gudimchuk, JR McIntosh - Nature reviews Molecular cell biology, 2021 - nature.com
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Actin–microtubule crosstalk in cell biology

M Dogterom, GH Koenderink - Nature reviews Molecular cell biology, 2019 - nature.com
The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Stretchable hydrogels with low hysteresis and anti-fatigue fracture based on polyprotein cross-linkers

H Lei, L Dong, Y Li, J Zhang, H Chen, J Wu… - Nature …, 2020 - nature.com
Hydrogel-based devices are widely used as flexible electronics, biosensors, soft robots, and
intelligent human-machine interfaces. In these applications, high stretchability, low …

The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

Z Xu, L Schaedel, D Portran, A Aguilar, J Gaillard… - Science, 2017 - science.org
Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …

Forcing cells into shape: the mechanics of actomyosin contractility

M Murrell, PW Oakes, M Lenz, ML Gardel - Nature reviews Molecular …, 2015 - nature.com
Actomyosin-mediated contractility is a highly conserved mechanism for generating
mechanical stress in animal cells and underlies muscle contraction, cell migration, cell …

Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment

VDL Putra, KA Kilian, ML Knothe Tate - Communications Biology, 2023 - nature.com
Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

The microtubule cytoskeleton in cardiac mechanics and heart failure

MA Caporizzo, BL Prosser - Nature Reviews Cardiology, 2022 - nature.com
The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …

Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …