Chromatography: An important tool for drug discovery

A Ahmad Dar, PL Sangwan… - Journal of separation …, 2020 - Wiley Online Library
Despite substantial developments of extraction and separation techniques, isolation of
natural products from natural sources is still a challenging task. Undoubtedly hybrid methods …

Recent bioanalytical methods for the isolation of bioactive natural products from genus Codonopsis

AA Dar, V Abrol, N Singh, EA Gashash… - Phytochemical …, 2023 - Wiley Online Library
Introduction Chromatography and spectroscopy are nowadays well‐validated techniques
allowing to isolate and purify different class of natural products from the genus Codonopsis …

Risk assessment, development and validation of a GC‐ECD‐based method for the quantification of cypermethrin from green pea

I Jan, AA Dar, AA Wani, M Mukhtar… - Biomedical …, 2022 - Wiley Online Library
The present work describes the persistence, dissipation behaviour, half‐life, risk assessment
and novel gas chromatography method for the residue estimation of cypermethrin in green …

Simultaneous quantification of losartan potassium and its active metabolite, EXP3174, in rabbit plasma by validated HPLC–PDA

TU Wani, KB Mir, A Raina, AA Dar, I Jan… - Biomedical …, 2023 - Wiley Online Library
Herein, we report a novel, accurate and cost‐effective validated analytical method for the
quantification of losartan potassium and its active metabolite, EXP 3174, in rabbit plasma by …

Dissipation and gas chromatographic method for the determination of profenofos residues in/on green pea and cucumber

AA Wani, AA Dar, I Jan, M Mukhtar… - Biomedical …, 2022 - Wiley Online Library
Herein we report a novel, accurate and cost‐effective gas chromatography method for the
determination of average deposits of profenofos on green pea and cucumber following good …

Method validation and simultaneous quantification of eight organochlorines/organophosphates in apple by gas chromatography

AA Wani, AA Dar, I Jan, KA Sofi… - Journal of the Science …, 2019 - Wiley Online Library
BACKGROUND The increasing and extensive use of pesticides worldwide has resulted in a
significant loss of non‐target populations particularly humans by direct or indirect exposures …

Development and validation of gas chromatography with electron capture detection method using QuEChERS for pesticide residue determination in cucumber

JA Sofi, AA Dar, I Jan, GI Hassan… - Biomedical …, 2023 - Wiley Online Library
A modified quick, easy, cheap, efficient, rugged, and safe (QuEChERS) method coupled to
gas chromatography with electron capture detection was developed for the simultaneous …

A convergent synthesis of novel alkyne–azide cycloaddition congeners of betulinic acid as potent cytotoxic agent

NA Dangroo, J Singh, SK Rath, N Gupta, A Qayum… - Steroids, 2017 - Elsevier
In an endeavour to develop potent anti-tumor agents from betulinic acid (BA), a series of C-
28 derived 1, 2, 3-triazolyl derivatives were designed and synthesized by employing Cu (I) …

Simultaneous quantification of eight bioactive secondary metabolites from Codonopsis ovata by validated high performance thin layer chromatography and their …

AA Dar, PL Sangwan, I Khan, N Gupta, A Qaudri… - … of Pharmaceutical and …, 2014 - Elsevier
Chemical investigation of Codonopsis ovata resulted in the isolation and identification of β-
sitosterol-3-O-glycoside, luteolin, apigenin, gentiacaulein, swertiaperenine, β-sitosterol …

Phytochemical study and biological evaluation of chemical constituents of Platanus orientalis and Platanus× acerifolia buds

QD Thai, J Tchoumtchoua, M Makropoulou, A Boulaka… - Phytochemistry, 2016 - Elsevier
One flavonol glycoside, two O-isoprenylated flavonols, one α, α-dimethylallyl flavonol, one
dihydrochalcone, two furanocoumarins and one terpenoid previously undescribed, along …