Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?

A Cruz Camacho, D Alfandari, E Kozela… - PLoS …, 2023 - journals.plos.org
Extracellular vesicles (EVs) provide a central mechanism of cell–cell communication. While
EVs are found in most organisms, their pathogenesis-promoting roles in parasites are of …

Giant vesicles and their use in assays for assessing membrane phase state, curvature, mechanics, and electrical properties

R Dimova - Annual review of biophysics, 2019 - annualreviews.org
Giant unilamellar vesicles represent a promising and extremely useful model biomembrane
system for systematic measurements of mechanical, thermodynamic, electrical, and …

The ESCRTs–converging on mechanism

M Remec Pavlin, JH Hurley - Journal of cell science, 2020 - journals.biologists.com
The endosomal sorting complexes required for transport (ESCRTs) I,-II and–III, and their
associated factors are a collection of∼ 20 proteins in yeast and∼ 30 in mammals …

Host invasion by pathogenic amoebae: epithelial disruption by parasite proteins

A Betanzos, C Bañuelos, E Orozco - Genes, 2019 - mdpi.com
The epithelium represents the first and most extensive line of defence against pathogens,
toxins and pollutant agents in humans. In general, pathogens have developed strategies to …

The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection

Y Avalos-Padilla, VN Georgiev, E Lantero… - PLoS …, 2021 - journals.plos.org
Infection with Plasmodium falciparum enhances extracellular vesicle (EV) production in
parasitized red blood cells (pRBCs), an important mechanism for parasite-to-parasite …

[HTML][HTML] Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3

H Haukedal, SS Lorenzen, EW Westi, GI Corsi… - Brain, Behavior, and …, 2023 - Elsevier
Frontotemporal dementia (FTD) is a common cause of early-onset dementia, with no current
treatment options. FTD linked to chromosome 3 (FTD3) is a rare sub-form of the disease …

Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico

L Harker-Kirschneck, B Baum, A Šarić - BMC biology, 2019 - Springer
Background ESCRT-III is a membrane remodelling filament with the unique ability to cut
membranes from the inside of the membrane neck. It is essential for the final stage of cell …

[HTML][HTML] Entamoeba histolytica: EhADH, an Alix Protein, Participates in Several Virulence Events through Its Different Domains

D Zanatta, A Betanzos, E Azuara-Liceaga… - International Journal of …, 2024 - mdpi.com
Entamoeba histolytica is the protozoan causative of human amoebiasis. The EhADH
adhesin (687 aa) is a protein involved in tissue invasion, phagocytosis and host-cell lysis …

Molecular interplays of the Entamoeba histolytica endosomal sorting complexes required for transport during phagocytosis

C Bañuelos, A Betanzos, R Javier-Reyna… - Frontiers in Cellular …, 2022 - frontiersin.org
Entamoeba histolytica, the causative agent of human amoebiasis, exhibits a continuous
membrane remodelling to exert its virulence properties. During this dynamic process, the …

Immune Response to the Enteric Parasite Entamoeba histolytica

E Uribe-Querol, C Rosales - Physiology, 2020 - journals.physiology.org
Entamoeba histolytica is a protozoan parasite responsible for amoebiasis, a disease with a
high prevalence in developing countries. Establishing an amoebic infection involves …