Chemotherapy-induced cognitive impairments: White matter pathologies

A Matsos, M Loomes, I Zhou, E Macmillan, I Sabel… - Cancer treatment …, 2017 - Elsevier
Whilst chemotherapeutic agents show promising results in the amelioration of cancerous
tumors, patients often experience cognitive disturbances associated with chemotherapy long …

[HTML][HTML] Distinct patterns of default mode and executive control network circuitry contribute to present and future executive function in older adults

CA Brown, FA Schmitt, CD Smith, BT Gold - NeuroImage, 2019 - Elsevier
Executive function (EF) performance in older adults has been linked with functional and
structural profiles within the executive control network (ECN) and default mode network …

[HTML][HTML] Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease

CA Brown, NF Johnson, AJ Anderson-Mooney… - NeuroImage: Clinical, 2017 - Elsevier
We developed a merged younger-older adult template of the fornix and demonstrated its
utility for studies of aging and preclinical Alzheimer's disease (AD). In Experiment 1 …

High cortical iron is associated with the disruption of white matter tracts supporting cognitive function in healthy older adults

V Zachariou, CE Bauer, C Pappas, BT Gold - Cerebral Cortex, 2023 - academic.oup.com
Aging is associated with brain iron accumulation, which has been linked to cognitive
decline. However, how brain iron affects the structure and function of cognitive brain …

Multi-compartment diffusion magnetic resonance imaging models link tract-related characteristics with working memory performance in healthy older adults

CE Bauer, V Zachariou, P Maillard… - Frontiers in Aging …, 2022 - frontiersin.org
Multi-compartment diffusion MRI metrics [such as metrics from free water elimination
diffusion tensor imaging (FWE-DTI) and neurite orientation dispersion and density imaging …

Contributions of white matter connectivity and BOLD modulation to cognitive aging: A lifespan structure-function association study

CE Webb, KM Rodrigue, DA Hoagey, CM Foster… - Cerebral …, 2020 - academic.oup.com
The ability to flexibly modulate brain activation to increasing cognitive challenge decreases
with aging. This age-related decrease in dynamic range of function of regional gray matter …

Data-driven brain network models differentiate variability across language tasks

K Bansal, JD Medaglia, DS Bassett… - PLoS computational …, 2018 - journals.plos.org
The relationship between brain structure and function has been probed using a variety of
approaches, but how the underlying structural connectivity of the human brain drives …

Differential age-related changes in structural covariance networks of human anterior and posterior hippocampus

X Li, Q Li, X Wang, D Li, S Li - Frontiers in physiology, 2018 - frontiersin.org
The hippocampus plays an important role in memory function relying on information
interaction between distributed brain areas. The hippocampus can be divided into the …

Age and Alzheimer's pathology disrupt default mode network functioning via alterations in white matter microstructure but not hyperintensities

CA Brown, Y Jiang, CD Smith, BT Gold - Cortex, 2018 - Elsevier
The default mode network (DMN) comprises defined brain regions contributing to internally-
directed thought processes. Reductions in task-induced deactivation in the DMN have been …

Dynamic range of frontoparietal functional modulation is associated with working memory capacity limitations in older adults

JG Hakun, NF Johnson - Brain and cognition, 2017 - Elsevier
Older adults tend to over-activate regions throughout frontoparietal cortices and exhibit a
reduced range of functional modulation during WM task performance compared to younger …