In the past few years, cancer immunotherapy has emerged as a safe and effective
alternative for treatment of cancers that do not respond to classical treatments, including …

The process of antibody-dependent cell-mediated cytotoxicity (ADCC) makes use of the
innate immune cells providing antitumor cytotoxicity activated by antibodies linked to target …

NF-κB is a transcription factor involved in the regulation of multiple physiological and
pathological cellular processes, including inflammation, cell survival, proliferation, and …

Cancer stem cells (CSCs) are the main drivers of disease progression and chemotherapy
resistance in breast cancer. Tumor progression and chemoresistance might then be …

For more than 20 years perforin and granzymes (GZMs) have been recognized as key cell
death executors of cytotoxic T (Tc) and natural killer (NK) cells during cancer …

Aggressive forms of breast cancer, such as Her2+ and triple negative breast cancer (TNBC),
are enriched in breast cancer stem cells (BCSC) and have limited therapeutic options …

Cell death plays two major complementary roles in T cell biology: mediating the removal of
cells that are targeted by T cells and the removal of T cells themselves. T cells serve as …

The growth and recurrence of a number of cancers is driven by a scarce population of
cancer stem cells (CSCs), which are resistant to most current therapies. It has been shown …

Despite HER2-targeted therapies improving the outcome of HER2+ breast cancer, many
patients experience resistance and metastatic progression. Cancer stem cells (CSC) play a …

Despite marked advancements in its treatment, breast cancer is still the second leading
cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem …