Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin
is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant …

The heme oxygenases (HOs), responsible for the degradation of heme to biliverdin/bilirubin,
free iron and CO, have been heavily implicated in mammalian CNS aging and disease. In …

Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how
bilirubin worsens outcomes remains mysterious. We report that post-, but not pre-, stroke …

Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that regulates the
expression of a number of antioxidant and detoxifying genes that provide cellular protection …

Heme oxygenase (HO)-1, involved in the heme degradation process, is an important
antioxidant enzyme. The induction of HO-1 gene expression, in response to diverse …

Reactive oxidative species (ROS) generated by environmental toxicants including pesticides
could be one of the factors underlying the neuronal cell damage in neurodegenerative …

Background The transcription factor Nrf2 (NF-E2-related factor 2) and its target gene
products, including heme oxygenase-1 (HO-1), elicit an antioxidant response that may have …

Excitotoxicity mediated by glutamate receptors may underlay the pathology of several
neurologic diseases. Considering that oxidative stress is central to excitotoxic damage, in …

The present article reviews the roles and interactions of iron and neuroinflammation in
Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial …

Status epilepticus (SE) can cause severe neuronal loss and oxidative damage. As
peroxisome proliferator-activated receptor gamma (PPARγ) agonists possess antioxidative …