A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology
X Wang, H Yu, R Gao, M Liu, W Xie - European Journal of Medical …, 2023 - Springer
Background The very-long-chain fatty acid elongase (ELOVL) family plays essential roles in
lipid metabolism and cellular functions. This comprehensive review explores the structural …
lipid metabolism and cellular functions. This comprehensive review explores the structural …
Lipids: Emerging Players of Microglial Biology
Lipids are small molecule immunomodulators that play critical roles in maintaining cellular
health and function. Microglia, the resident immune cells of the central nervous system …
health and function. Microglia, the resident immune cells of the central nervous system …
Identifying MSMO1, ELOVL6, AACS, and CERS2 related to lipid metabolism as biomarkers of Parkinson's disease
H Wang, M Zhao, G Chen, Y Lin, D Kang, L Yu - Scientific Reports, 2024 - nature.com
The mechanisms underlying lipid metabolic disorders in Parkinson's diseases (PD) remain
unclear. Weighted Gene Co-Expression Network Analysis (WGCNA) was conducted to …
unclear. Weighted Gene Co-Expression Network Analysis (WGCNA) was conducted to …
Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders
A Villoria-González, B Zierfuss, P Parzer, E Heuböck… - Biomolecules, 2023 - mdpi.com
Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and
secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight …
secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight …
The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis
F Van Gaever, F Mingneau, S Vanherle… - Frontiers in …, 2024 - frontiersin.org
Introduction Over the past few decades, there has been a sudden rise in the incidence of
Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited …
Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited …
Emerging insights on the role of Elovl6 in human diseases: Therapeutic challenges and opportunities
J Guo, S Xue, X Wang, L Wang, SY Wen - Life Sciences, 2024 - Elsevier
Abstract ELOVL6, elongation-of-very-long-chain-fatty acids 6, a crucial enzyme in lipid
metabolism, primarily responsible for the elongation of carbon chains of C12-C16 saturated …
metabolism, primarily responsible for the elongation of carbon chains of C12-C16 saturated …
Identification of lipid metabolism-related gene markers and construction of a diagnostic model for multiple sclerosis: an integrated analysis by bioinformatics and …
F Yang, X Li, J Wang, Z Duan, C Ren, P Guo… - Analytical …, 2025 - Elsevier
Background Multiple sclerosis (MS) is an autoimmune inflammatory disorder that causes
neurological disability. Dysregulated lipid metabolism contributes to the pathogenesis of MS …
neurological disability. Dysregulated lipid metabolism contributes to the pathogenesis of MS …