Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Small molecule is a kind of low molecular weight organic compound with variety of
biological functions. Studies have indicated that small molecules can inhibit a specific …

One of the most fascinating discoveries in molecular oncology has been that cancer
represents a disease in which genetic alterations in protein-coding, but also in non-coding …

Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets.
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …

The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

Aberrant expression of miRNAs is critically implicated in cancer initiation and progression.
Therapeutic approaches focused on regulating miRNAs are therefore a promising approach …

The biological role of the existence of overlapping structures in RNA is possible yet remains
very unexplored. G-Rich tracts of RNA form G-quadruplexes, while GC-rich sequences …

Despite considerable progress being made in understanding pancreatic cancer (PC)
pathogenesis, it still remains the 10th most often diagnosed malignancy in the world and 4th …