The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

In recent decades, the impairment of cholesterol metabolism in the pathogenesis of
Alzheimer's disease (AD) has been intensively investigated, and it has been recognized to …

Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Background Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a
cascade of pathological changes in Alzheimer's disease (AD), and inhibiting BACE1, which …

Abstract Purpose of Review An epidemic of age-associated cognitive decline, most
commonly ascribed to neurodegenerative conditions such as Alzheimer's and Parkinson's …

Alzheimer's disease is a neurodegenerative disease that affects a large proportion of older
adult people and is characterized by memory loss, progressive cognitive impairment, and …

Alzheimer's disease (AD) is the most common form of dementia, and ginsenoside Rg2 (Rg2)
is proven to inhibit AD's progression. This study investigates the potential benefits of Rg2 …

Introduction Subcortical small‐vessel disease (SSVD) is the most common vascular
cognitive disorder. However, because no disease‐specific cerebrospinal fluid (CSF) …

It is well known that amyloid precursor protein (APP), the enzyme β-secretase 1 (BACE1),
cyclooxygenase 2 (COX-2), nicastrin (NCT), and hyperphosphorylated tau protein (p-tau) …

Objective We estimated the conversion from cognitively normal to mild cognitive impairment
(MCI) to probable dementia and death for underweight, normal, overweight, and obese older …