Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease
L Jia, J Piña-Crespo, Y Li - Molecular brain, 2019 - Springer
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
Effects of neurological disorders on bone health
RR Kelly, SJ Sidles, AC LaRue - Frontiers in psychology, 2020 - frontiersin.org
Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …
life and can negatively affect bone health. The brain-bone axis is critically important for …
Aberrant excitatory–inhibitory synaptic mechanisms in entorhinal cortex microcircuits during the pathogenesis of Alzheimer's disease
AL Petrache, A Rajulawalla, A Shi, A Wetzel… - Cerebral …, 2019 - academic.oup.com
Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …
Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer's Disease and Osteoporosis
HS Wang, SJ Karnik, TJ Margetts, LI Plotkin… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This comprehensive review discusses the complex relationship
between Alzheimer's disease (AD) and osteoporosis, two conditions that are prevalent in the …
between Alzheimer's disease (AD) and osteoporosis, two conditions that are prevalent in the …
[HTML][HTML] Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices
C Ruggiero, M Baroni, D Xenos, L Parretti… - Ageing research …, 2024 - Elsevier
Dementia, osteoporosis, and fragility fractures are chronic diseases, often co-existing in
older adults. These conditions pose severe morbidity, long-term disability, and mortality, with …
older adults. These conditions pose severe morbidity, long-term disability, and mortality, with …
From the mind to the spine: the intersecting world of Alzheimer's and osteoporosis
TJ Margetts, HS Wang, SJ Karnik, LI Plotkin… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This comprehensive review delves into the intricate interplay
between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with …
between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with …
Crosstalk of brain and bone—clinical observations and their molecular bases
E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …
[HTML][HTML] IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice
Hallmark features of Alzheimer's disease (AD) include elevated accumulation of aggregated
Aβ40 and Aβ42 peptides, hyperphosphorylated Tau (p-Tau), and neuroinflammation …
Aβ40 and Aβ42 peptides, hyperphosphorylated Tau (p-Tau), and neuroinflammation …
Mind the gap: unraveling the intricate dance between Alzheimer's disease and related dementias and bone health
Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …
Alzheimer's disease and impaired bone microarchitecture, regeneration and potential genetic links
M Zhang, S Hu, X Sun - Life, 2023 - mdpi.com
Alzheimer's Disease (AD) and osteoporosis are both age-related degenerative diseases.
Many studies indicate that these two diseases share common pathogenesis mechanisms. In …
Many studies indicate that these two diseases share common pathogenesis mechanisms. In …