Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Hepatic stellate cells (HSCs) activation play a significant role in the progression of hepatic
fibrosis. During chronic liver diseases, hepatocytes are damaged severely and secrete …

Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

Hepatocellular carcinoma (HCC) is a common and deadly cancer. Most cases of HCC arise
in a cirrhotic/fibrotic liver, indicating that environment may play a paramount role in cancer …

MicroRNAs (miRNAs) are single-stranded, endogenous non-coding small RNAs, ranging
from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …

Idiopathic pulmonary fibrosis (IPF) is characterized by chronic inflammation, severe scarring,
and stem cell senescence. Stem cell-based therapies modulate inflammatory and fibrogenic …