Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Inflammasomes continue to generate interest in an increasing number of disciplines owing
to their unique ability to integrate a myriad of signals from pathogen‐and damage …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis
resistance and be therapeutically targeted. Compared to normal cells, several human …

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

Several bacterial species can generate hydrogen sulfide (H2S). Study evidence favors the
view that the microbiome of the colon harbors increased amounts of H2S producing bacteria …

Pesticides are widely used in agricultural and other settings, resulting in continued human
exposure. Pesticide toxicity has been clearly demonstrated to alter a variety of neurological …

Dysfunction of mitochondrial complex I is a feature of human neurodegenerative diseases
such as Leber hereditary optic neuropathy and Parkinson's disease. This mitochondrial …

The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis
induction by various stimuli including cytotoxic stress. It depends on the cellular context …