Abstract The Epstein‐Barr virus (EBV) can choose between two alternative lifestyles; latent
or lytic replication. In the latent state, the EBV genomic DNA, which exists as a closed …

An important reason for preferring mammalian cells for heterologous gene expression is
their ability to make authentic proteins containing post‐translational modifications similar to …

In Saccharomyces cerevisiae, more than 80% of the∼ 6200 predicted genes are
nonessential, implying that the genome is buffered from the phenotypic consequences of …

ABSTRACT Kaposi's sarcoma (KS)-associated herpesvirus (KSHV)(also known as human
herpesvirus 8) latently infects KS tumors, primary effusion lymphomas (PELs), and PEL cell …

Epstein–Barr virus (EBV) replicates in its latent phase once per cell cycle in proliferating B
cells. The latent origin of DNA replication, oriP, supports replication and stable maintenance …

The 165-kb chromosome of Epstein–Barr virus (EBV) is replicated by cellular enzymes only
once per cell cycle in human cells that are latently infected. Here, we report that the human …

Epstein–Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent
infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the …

The duplication of the mammalian genome is an organized event, but there is limited
information about the precision of the duplication program at specific genetic loci. We …

Replication and maintenance of the 170-kb circular chromosome of Epstein-Barr virus (EBV)
during latent infection are generally believed to depend upon a single viral gene product …

The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in
all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer …