Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

I Talon, A Janiszewski, B Theeuwes, T Lefevre, J Song… - Genome Biology, 2021 - Springer
Background Precise gene dosage of the X chromosomes is critical for normal development
and cellular function. In mice, XX female somatic cells show transcriptional X chromosome …

Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos

HC Naik, K Hari, D Chandel, MK Jolly, S Gayen - Iscience, 2022 - cell.com
In mammals, transcriptional inactivation of one X chromosome in female compensates for
the dosage of X-linked gene expression between the sexes. Additionally, it is believed that …

A temporally controlled sequence of X-chromosome inactivation and reactivation defines female mouse in vitro germ cells with meiotic potential

J Severino, M Bauer, T Mattimoe, N Arecco, L Cozzuto… - bioRxiv, 2021 - biorxiv.org
The early mammalian germ cell lineage is characterized by extensive epigenetic
reprogramming, which is required for the maturation into functional eggs and sperm. In …

X upregulation is not global and extent of upregulation differs between ancestral and acquired X-linked genes

CH Naik, K Hari, D Chandel, MK Jolly, S Gayen - bioRxiv, 2021 - biorxiv.org
Recent studies have provided substantial evidence supporting Ohno's hypothesis that
upregulation of active X chromosome genes balances the dosage of X-linked gene …