Current advances in digital cognitive assessment for preclinical Alzheimer's disease

F Öhman, J Hassenstab, D Berron… - Alzheimer's & …, 2021 - Wiley Online Library
There is a pressing need to capture and track subtle cognitive change at the preclinical
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …

The efficacy of cognitive intervention in mild cognitive impairment (MCI): a meta-analysis of outcomes on neuropsychological measures

DS Sherman, J Mauser, M Nuno, D Sherzai - Neuropsychology review, 2017 - Springer
Cognitive training in MCI may stimulate pre-existing neural reserves or recruit neural
circuitry as “compensatory scaffolding” prompting neuroplastic reorganization to meet task …

Blood–brain barrier link to human cognitive impairment and Alzheimer's disease

G Barisano, A Montagne, K Kisler… - Nature cardiovascular …, 2022 - nature.com
Vascular dysfunction is frequently observed in disorders associated with cognitive
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …

Loneliness and cognitive function in older adults without dementia: A systematic review and meta-analysis

KD Harrington, S Vasan, JE Kang… - Journal of …, 2023 - journals.sagepub.com
Background: Loneliness has been highlighted as a risk factor for dementia. However, the
nature of the relationship between loneliness and cognitive function prior to onset of …

Diagnostic accuracy of memory measures in Alzheimer's dementia and mild cognitive impairment: A systematic review and meta-analysis

GH Weissberger, JV Strong, KB Stefanidis… - Neuropsychology …, 2017 - Springer
With an increasing focus on biomarkers in dementia research, illustrating the role of
neuropsychological assessment in detecting mild cognitive impairment (MCI) and …

When does cognitive decline begin? A systematic review of change point studies on accelerated decline in cognitive and neurological outcomes preceding mild …

JE Karr, RB Graham, SM Hofer… - Psychology and …, 2018 - psycnet.apa.org
Older adults who ultimately develop dementia experience accelerated cognitive decline
long before diagnosis. A similar acceleration in cognitive decline occurs in the years before …

Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults

AJ Weigand, MW Bondi, KR Thomas, NL Campbell… - Neurology, 2020 - AAN Enterprises
Objective To determine the cognitive consequences of anticholinergic medications (aCH) in
cognitively normal older adults as well as interactive effects of genetic and CSF Alzheimer …

Normative data for the symbol digit modalities test in older white Australians and Americans, African-Americans, and Hispanic/Latinos

J Ryan, RL Woods, CJ Britt, AM Murray… - Journal of …, 2020 - journals.sagepub.com
Background: Processing speed, which can be assessed using the Symbol Digit Modalities
Test (SDMT), is central to many brain functions. Processing speed declines with advanced …

Early Detection of Amyloid‐Related Changes in Memory among Cognitively Unimpaired Older Adults with Daily Digital Testing

KV Papp, RJ Jutten, D Soberanes… - Annals of …, 2024 - Wiley Online Library
Objective This study was undertaken to determine whether assessing learning over days
reveals Alzheimer disease (AD) biomarker‐related declines in memory consolidation that …

Evidence for reduced autobiographical memory episodic specificity in cognitively normal middle-aged and older individuals at increased risk for Alzheimer's disease …

MD Grilli, AA Wank, JJ Bercel, L Ryan - Journal of the International …, 2018 - cambridge.org
Objectives: Alzheimer's disease (AD) typically eludes clinical detection for years, if not
decades. The identification of subtle cognitive decline associated with preclinical AD would …