Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …

An interoception model for the acute exercise-cognition interaction is presented. During
exercise following the norepinephrine threshold, interoceptive feedback induces increased …

The brain is a highly metabolically active tissue that critically relies on oxidative
phosphorylation as a means for maintaining energy. One result of this process is the …

Oxidative stress is the subject of numerous studies, most of them focusing on the negative
effects exerted at both molecular and cellular levels, ignoring the possible benefits of free …

Currently, the oxidative stress (or free radical) theory of aging is the most popular
explanation of how aging occurs at the molecular level. While data from studies in …

The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …