Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem
cells capable of self-renewing and differentiating to virtually every pseudostratified …

Purpose: Compelling evidence supports the presence of P450 enzymes (CYPs) in the
central nervous system (CNS). However, little information is available on the localization and …

Methotrexate (MTX), as a chemotherapeutic drug, is widely used in the therapy of several
cancer types. The efficiency of drug treatment is compromised by the appearance of …

T lymphoblastic leukemia (T-ALL) is an aggressive haematolymphoid malignancy
comprising 15% of acute lymphoblastic leukemia (ALL). Although its prognosis has …

Targeted delivery of chemotherapeutics in order to overcome side effects and enhance
chemosensitivity remains a major issue in cancer research. In this context, biocompatible oil …

During the last decade, many studies have been reported on the design and formulation of
novel drug delivery systems proposed for dermal or transdermal administration. The efforts …

This book presents modern trends that regard the utilization of advanced functional
materials for the development of innovative pharmaceuticals. Such materials include classes …

This chapter is a systemic review of the literature spanning the last five years, focusing on
the use of nano-dispersions as efficient drug delivery systems in dermal applications …

Despite advances in the understanding of tumor biology in recent years, lung cancer
remains the leading cause of cancer death worlwide. Non small cell lung cancer (NSCLC; …

Methylating agents, a widely used class of anticancer drugs, induce DNA methylation
adducts, the most biologically significant being O6-methylguanine. The efficacy of these …