The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

Neutrophil granulocytes, or neutrophils, are the most abundant circulating leukocytes in
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …

The balance between a protective and a destructive immune response can be precarious,
as exemplified by inborn errors in nucleotide metabolism. This class of inherited disorders …

Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and
pyroptosis act as critical natural immune signaling axes for microbial infection, chronic …

The understanding of immune dysregulation in many different diseases continues to grow.
There is increasing evidence that altered microbiome and gut barrier dysfunction contribute …

Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases;
pathomechanisms that regulate extravasation of damaging immune cells into surrounding …

IFN-signaling gene (ISG) expression scores are potential markers of inflammation with
significance from cancer to genetic syndromes. In Aicardi Goutières Syndrome (AGS), a …

The discovery of interferon in the 1950s represents much more than the identification of the
first cytokine and the key mediator of antiviral host defense. Defining the molecular nature …

Patients with rare and complex rheumatic diseases (RDs) present with immense clinical
variability inherent to all immunologic diseases. In addition to systemic and organ‐specific …

Since first being documented in ancient times, the relation of inflammation with injury and
disease has evolved in complexity and causality. Early observations supported a cause …