IL‐1β and IL‐18: inflammatory markers or mediators of hypertension?

SM Krishnan, CG Sobey, E Latz… - British journal of …, 2014 - Wiley Online Library
Chronic inflammation in the kidneys and vascular wall is a major contributor to hypertension.
However, the stimuli and cellular mechanisms responsible for such inflammatory responses …

Endothelium-dependent effects of statins

S Wolfrum, KS Jensen, JK Liao - Arteriosclerosis, thrombosis, and …, 2003 - Am Heart Assoc
The vascular endothelium is a dynamic endocrine organ that regulates contractile, secretory,
and mitogenic activities in the vessel wall and hemostatic processes within the vascular …

Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension

KE Ferrier, MH Muhlmann, JP Baguet… - Journal of the American …, 2002 - jacc.org
Objectives: We sought to investigate the effects of intensive cholesterol reduction on large
artery stiffness and blood pressure in normolipidemic patients with isolated systolic …

The lipid and non-lipid effects of statins

AS Wierzbicki, R Poston, A Ferro - Pharmacology & therapeutics, 2003 - Elsevier
The 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, more
commonly known as statins, are a class of drug widely used for the treatment of …

LIPITENSION: Interplay between dyslipidemia and hypertension

JJ Dalal, TNC Padmanabhan, P Jain… - Indian journal of …, 2012 - journals.lww.com
The burden of cardiovascular disease (CVD) is increasing worldwide. The increase in the
burden is a major concern in developing countries like India. It is well-established that …

Prevalence of uncontrolled hypertension and its associated factors in 50–74 years old Iranian adults: a population-based study

F Farhadi, R Aliyari, H Ebrahimi, H Hashemi… - BMC Cardiovascular …, 2023 - Springer
Background By the lengthening of life span, the incidence of chronic diseases such as
hypertension and uncontrolled hypertension has increased. This study aims to determine …

Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide–Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E−/− Mice In Vivo

M Pelat, C Dessy, P Massion, JP Desager, O Feron… - Circulation, 2003 - Am Heart Assoc
Background—Decreased heart rate variability (HRV) and increased blood pressure
variability (BPV), determined in part by nitric oxide (NO)–dependent endothelial dysfunction …

Statins and stroke

M Endres - Journal of Cerebral Blood Flow & Metabolism, 2005 - journals.sagepub.com
Inhibitors of HMG-CoA reductase (statins) are potent cholesterol-lowering drugs. Large
clinical trials have shown that statins reduce the incidence of cerebrovascular events, which …

Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial

BA Golomb, JE Dimsdale, HL White… - Archives of internal …, 2008 - jamanetwork.com
Background Some studies have suggested reductions in blood pressure (BP) with statin
treatment, particularly in persons with hypertension. Randomized trial evidence is limited …

Hypertension and dyslipidaemia in obesity and insulin resistance: pathophysiology, impact on atherosclerotic disease and pharmacotherapy

MJ Chapman, AC Sposito - Pharmacology & therapeutics, 2008 - Elsevier
Hypertension, a prevalent risk factor for cardiovascular disease, frequently occurs in
conjunction with metabolic disturbances and in particular with dyslipidaemia; such …