Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research

M Ramirez-Garrastacho, C Bajo-Santos, A Line… - British journal of …, 2022 - nature.com
Prostate cancer is a global cancer burden and considerable effort has been made through
the years to identify biomarkers for the disease. Approximately a decade ago, the potential of …

Single-exosome-counting immunoassays for cancer diagnostics

C Liu, X Xu, B Li, B Situ, W Pan, Y Hu, T An, S Yao… - Nano …, 2018 - ACS Publications
Exosomes shed by tumor cells have been recognized as promising biomarkers for cancer
diagnostics due to their unique composition and functions. Quantification of low …

Single particle automated Raman trapping analysis of breast cancer cell-derived extracellular vesicles as cancer biomarkers

J Penders, A Nagelkerke, EM Cunnane, SV Pedersen… - ACS …, 2021 - ACS Publications
Extracellular vesicles (EVs) secreted by cancer cells provide an important insight into cancer
biology and could be leveraged to enhance diagnostics and disease monitoring. This paper …

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

KB Johnsen, JM Gudbergsson, TL Andresen… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Circulating biomarkers have a great potential in diagnosing cancer diseases at early stages,
where curative treatment is a realistic possibility. In the recent years, using extracellular …

Extracellular vesicles: techniques and biomedical applications related to single vesicle analysis

J Zhang, J Wu, G Wang, L He, Z Zheng, M Wu… - ACS …, 2023 - ACS Publications
Extracellular vesicles (EVs) are extensively dispersed lipid bilayer membrane vesicles
involved in the delivery and transportation of molecular payloads to certain cell types to …

Fourier transform infrared spectroscopy as a cancer screening and diagnostic tool: a review and prospects

KY Su, WL Lee - Cancers, 2020 - mdpi.com
Infrared spectroscopy has long been used to characterize chemical compounds, but the
applicability of this technique to the analysis of biological materials containing highly …

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

M Lombardi, R Parolisi, F Scaroni, E Bonfanti… - Acta …, 2019 - Springer
Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …

Single extracellular vesicle analysis for early cancer detection

S Ferguson, KS Yang, R Weissleder - Trends in molecular medicine, 2022 - cell.com
Extracellular vesicles (EVs) are actively shed into the circulation from both cancer and host
cells. EVs are emerging as one of the diagnostic frontrunners for early cancer detection …

Molecular fingerprint detection using Raman and infrared spectroscopy technologies for cancer detection: a progress review

S Zhang, Y Qi, SPH Tan, R Bi, M Olivo - Biosensors, 2023 - mdpi.com
Molecular vibrations play a crucial role in physical chemistry and biochemistry, and Raman
and infrared spectroscopy are the two most used techniques for vibrational spectroscopy …