SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …

SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through …

Club cells are found in human small airways where they play an important role in immune
defense, xenobiotic metabolism, and repair after injury. Over the past few years, data from …

Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …

Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian,
swine and human IAV bind sialic acid on host glycans as receptor, whereas some bat IAV …

We engineered an ultrasensitive reporter of p16 INK4a, a biomarker of cellular senescence.
Our reporter detected p16 INK4a-expressing fibroblasts with certain senescent …

The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow
cytometry and single cell RNA-sequencing to understand how the heterogeneity of this …

Background: Eosinophils have numerous roles in type 2 inflammation depending on their
activation states in the blood and airway or after encounter with inflammatory mediators …

Epithelial tissues provide front-line barriers shielding the organism from invading pathogens
and harmful substances. In the airway epithelium, the combined action of multiciliated and …

IL-13–induced goblet cell metaplasia contributes to airway remodeling and pathological
mucus hypersecretion in asthma. miRNAs are potent modulators of cellular responses, but …