Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance

D Sun, J Wang, S Toan, D Muid, R Li, X Chang, H Zhou - Angiogenesis, 2022 - Springer
Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

Notch signalling in healthy and diseased vasculature

F Del Gaudio, D Liu, U Lendahl - Open Biology, 2022 - royalsocietypublishing.org
Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

[HTML][HTML] Vascular changes in the cycling and early pregnant uterus

N Massri, R Loia, JL Sones, R Arora, NC Douglas - JCI insight, 2023 - ncbi.nlm.nih.gov
Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium.
Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and …

Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia

H Qu, RA Khalil - Biochemical Pharmacology, 2022 - Elsevier
Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …

[HTML][HTML] Jiawei Shoutai Pill promotes decidualization by regulating the SGK1/ENaC pathway in recurrent spontaneous abortion

X Di, Z Duan, Y Ma, X Song, Y Hao, G Li, Z Tan… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Jiawei Shoutai Pill (JWSTW) is a traditional
herbal formula for recurrent spontaneous abortion (RSA). Although JWSTW significantly …

[Retracted] Protective Effect of Nicorandil on Cardiac Microvascular Injury: Role of Mitochondrial Integrity

X Jiang, D Wu, Z Jiang, W Ling… - Oxidative Medicine and …, 2021 - Wiley Online Library
A major shortcoming of postischemic therapy for myocardial infarction is the no‐reflow
phenomenon due to impaired cardiac microvascular function including microcirculatory …

BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3

J Wang, X Wang, W Du, Z Xue, W Huang, Z Guan… - Cellular signalling, 2022 - Elsevier
It has been suggested that mitochondrial dysfunction underlies the myocardial injury seen
following cardiorenal syndrome type 3 (CRS-3). Both mitophagy and the mitochondrial …

Proteolysis in reproduction: lessons from gene-modified organism studies

D Kiyozumi, M Ikawa - Frontiers in Endocrinology, 2022 - frontiersin.org
The physiological roles of proteolysis are not limited to degrading unnecessary proteins.
Proteolysis plays pivotal roles in various biological processes through cleaving peptide …

Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction

E Klapproth, A Witt, P Klose, J Wiedemann… - Nature …, 2022 - nature.com
After myocardial infarction the innate immune response is pivotal in clearing of tissue debris
as well as scar formation, but exaggerated cytokine and chemokine secretion with …

[PDF][PDF] RETRACTED: Molecular Perspectives of Mitophagy in Myocardial Stress: Pathophysiology and Therapeutic Targets

H Ji, D Wu, OM Kimberlee, R Li, G Qian - Frontiers in physiology, 2021 - frontiersin.org
A variety of complex risk factors and pathological mechanisms contribute to myocardial
stress, which ultimately promotes the development of cardiovascular diseases, including …