Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs.
Instead they have voltage‐dependent channels that provide the capacity to generate a very …

After complete spinal cord transections that removed all supraspinal inputs in adult rats,
combinations of serotonergic agonists and epidural electrical stimulation were able to …

Neurons in the brainstem implicated in the initiation of locomotion include glutamatergic,
noradrenergic (NA), dopaminergic (DA), and serotonergic (5-HT) neurons giving rise to …

The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …

In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

Descending monoaminergic inputs markedly influence spinal locomotor circuits, but the
functional relationships between specific receptors and the control of walking behavior …

Dendrites contain voltage-sensitive conductances that, in vivo, can be influenced by
neuromodulatory inputs. In spinal motoneurons, dendrites have voltage-activated persistent …

Serotonin (5-HT), a monoamine neurotransmitter synthesized in various populations of
brainstem neurons, plays an important role in modulating the activity of spinal networks …

Locomotion can be induced in rodents by direct application 5-hydroxytryptamine (5-HT) onto
the spinal cord. Previous studies suggest important roles for 5-HT7 and 5-HT2A receptors in …