Selecting the appropriate formulation and solubility-enabling technology for poorly water
soluble drugs is an essential element in the development of formulations for paediatric …

The dissolution, intestinal absorption and presystemic metabolism of a drug depend on its
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …

Orodispersible tablets are an excellent alternative regarding drug administration in pediatric
patients. Nowadays there are alternatives to the compression process including; molding …

Background Recent position papers and guidelines encourage women with epilepsy (WWE)
to exclusively breastfeed their infants because the benefits to their infants outweigh the …

This study aimed to mask fluconazole (FLU) taste and improve its rheological properties by
an efficient process of cyclodextrin complexation. For this, hot-melt extrusion (HME) was …

Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

Due to the lack of age-appropriate formulations for children, healthcare professionals and
caregivers frequently manipulate dosage forms to facilitate oral administration and obtain …

The objective was using the Essential Medicines List for children by the World Health
Organization (WHO) to create a pediatric biopharmaceutics classification system (pBCS) of …

Postabsorptive factors which can affect systemic drug exposure are assumed to be
dependent on the active pharmaceutical ingredient (API), and thus independent of …

Objectives In this review, the current biopharmaceutical approaches for evaluation of oral
formulation performance in paediatrics are discussed. Key findings The paediatric …