The inhibitory effects of polyanionic substances on the replication of herpes simplex virus
(HSV) and other viruses were reported almost four decades ago. However, these …

Established for 20 years as the definitive virology reference, the two-volume classic Fields
Virology is in its thoroughly revised, updated Fifth Edition. More than 100 world-renowned …

Nearly four generations of investigators have studied combined drug effects. Their methods
of generating and analyzing data have changed dramatically over the years but the basic …

The development of antiretroviral therapy against acquired immunodeficiency syndrome
(AIDS) has been an intense research effort since the discovery of the causative agent …

The cell surface of mammalian cells is capable of reductively cleaving disulfide bonds of
exogenous membrane-bound macromolecules (for instance, the interchain disulfide of …

The acquired immunodeficiency syndrome (AIDS) epidemic has had a profound impact on
our understanding of Kaposi's sarcoma (KS). Epidemiologic features suggest a sexually …

Purpose The metabolic disturbances seen during infection are thought to be due to
cytokines, modulators of the immune response. The acquired immunodeficiency syndrome …

Depending on the stage of their intervention with the viral replicative cycle, human
immunodeficiency virus inhibitors could be divided into the following groups:(i) adsorption …

The T-cell surface glycoprotein, CD4 (T4), acts as the cellular receptor for human
immunodeficiency virus, type 1 (HIV-1), the first member of the family of viruses that cause …

▪ Zidovudine, a nucleoside analog, was the first agent proved to be effective in the
management of human immunodeficiency virus type 1 (HIV-1) infection. After demonstration …