Heat shock proteins as immunomodulants

T Zininga, L Ramatsui, A Shonhai - Molecules, 2018 - mdpi.com
Heat shock proteins (Hsps) are conserved molecules whose main role is to facilitate folding
of other proteins. Most Hsps are generally stress-inducible as they play a particularly …

Heat shock protein 70 as a double agent acting inside and outside the cell: insights into autoimmunity

S Tukaj - International Journal of Molecular Sciences, 2020 - mdpi.com
Heat shock proteins (Hsp) are a diverse group of constitutive and/or stress-induced
molecules that are categorized into several classes on the basis of their molecular weight …

Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories

S Hassamal - Frontiers in psychiatry, 2023 - frontiersin.org
In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

The role of extracellular HSP70 in the function of tumor-associated immune cells

M Linder, E Pogge von Strandmann - Cancers, 2021 - mdpi.com
Simple Summary The intracellular heat shock protein 70 (HSP70) is essential for cells to
respond to stress, for instance, by refolding damaged proteins or inhibiting apoptosis …

NLRP3 inflammasome activation, metabolic danger signals, and protein binding partners

SY Leu, YL Tsang, LC Ho, CC Yang… - Journal of …, 2023 - joe.bioscientifica.com
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an
oligomeric complex that assembles in response to exogenous signals of pathogen infection …

[HTML][HTML] Shear stress induces monocyte/macrophage-mediated inflammation by upregulating cell-surface expression of heat shock proteins

H Son, HS Choi, SE Baek, YH Kim, J Hur… - Biomedicine & …, 2023 - Elsevier
The loss of endothelial cells is associated with the accumulation of monocytes/macrophages
underneath the surface of the arteries, where cells are prone to mechanical stimulation, such …

Extracellular heat shock protein 70 increases the glucocorticoid receptor and dual-specificity phosphatase 1 via toll-like receptor 4 and attenuates inflammation in …

L Zhou, L Fang, M Tamm, D Stolz, M Roth - International Journal of …, 2023 - mdpi.com
Heat shock protein 70 (HSP70) regulates the ligand binding of the glucocorticoid receptor
(GR). In asthma patients, heat treatment increased both the GR expression and secretion of …

Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?

M Krause, F Gerchman, R Friedman - Diabetology & Metabolic Syndrome, 2020 - Springer
Chronic inflammation is involved in the pathogenesis of several metabolic diseases, such as
obesity and type 2 diabetes mellitus (T2DM). With the recent worldwide outbreak of …

Rationale for 1068 nm photobiomodulation therapy (PBMT) as a novel, non-invasive treatment for COVID-19 and other coronaviruses: roles of NO and hsp70

LC Kitchen, M Berman, J Halper, P Chazot - International Journal of …, 2022 - mdpi.com
Researchers from across the world are seeking to develop effective treatments for the
ongoing coronavirus disease 2019 (COVID-19) outbreak, which arose as a major public …

Keratins as an inflammation trigger point in epidermolysis bullosa simplex

NA Evtushenko, AK Beilin, AV Kosykh… - International Journal of …, 2021 - mdpi.com
Epidermolysis bullosa simplex (EBS) is a group of inherited keratinopathies that, in most
cases, arise due to mutations in keratins and lead to intraepidermal ruptures. The cellular …