Epigenome editing technologies for discovery and medicine
Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …
include elucidating gene regulation mechanisms, annotating coding and noncoding …
Hepatocyte reprogramming in liver regeneration: biological mechanisms and applications
The liver is one of the few organs that retain the capability to regenerate in adult mammals.
This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes …
This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes …
From time-series transcriptomics to gene regulatory networks: A review on inference methods
M Marku, V Pancaldi - PLOS Computational Biology, 2023 - journals.plos.org
Inference of gene regulatory networks has been an active area of research for around 20
years, leading to the development of sophisticated inference algorithms based on a variety …
years, leading to the development of sophisticated inference algorithms based on a variety …
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML
Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of poorly
differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 …
differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 …
Cell reprogramming design by transfer learning of functional transcriptional networks
Recent developments in synthetic biology, next-generation sequencing, and machine
learning provide an unprecedented opportunity to rationally design new disease treatments …
learning provide an unprecedented opportunity to rationally design new disease treatments …
Reproducibility and FAIR principles: the case of a segment polarity network model
P Mendes - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
The issue of reproducibility of computational models and the related FAIR principles
(findable, accessible, interoperable, and reusable) are examined in a specific test case. I …
(findable, accessible, interoperable, and reusable) are examined in a specific test case. I …
Pharos and TCRD: Informatics Tools for Illuminating Dark Targets
Summary The Illuminating the Druggable Genome (IDG) program, a National Institutes of
Health Common Fund Program, started in 2013 to improve our understanding of …
Health Common Fund Program, started in 2013 to improve our understanding of …
Combinatorial Optimization for Predicting Optimal Cell-state Conversion Paths
S Agrawal, M Kellis, M Wohlwend - 2023 16th International …, 2023 - ieeexplore.ieee.org
Cellular reprogramming constitutes a crucial, yet unexplored field that studies the
manipulation of cell states through transcriptomic changes. Our study aims to expand …
manipulation of cell states through transcriptomic changes. Our study aims to expand …
CRGEM: Cellular Reprogramming using mechanism-driven Gene Expression Modulation
Introduction Regenerative medicine promises a cure for currently incurable diseases and
pathological conditions. Its central idea is to leverage healthy cells to regenerate diseased …
pathological conditions. Its central idea is to leverage healthy cells to regenerate diseased …
[PDF][PDF] Computational workflow for predicting transcriptional modulation to achieve therapeutically desired cellular conversion for regenerative medicine
Introduction Regenerative medicine promises cure for currently incurable diseases and
pathological conditions. Its central idea is to leverage healthy cells to regenerate diseased …
pathological conditions. Its central idea is to leverage healthy cells to regenerate diseased …