The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the
organism from chemical, microbial, and physical challenges which is indispensable for …

Disruptions in the intestinal epithelial barrier can result in devastating consequences and a
multitude of disease syndromes, particularly among preterm neonates. The association …

A single layer of epithelial cells lines the small and large intestines and functions as a barrier
between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) …

Teleost mucosal immunity has become the subject of unprecedented research studies in
recent years because of its diversity and defining characteristics. Its immune repertoire is …

Consumption of diets high in fat and calories leads to hyperphagia and obesity, which is
associated with chronic “low-grade” systemic inflammation. Ingestion of a high-fat diet alters …

Toll-like receptors (TLRs) play a crucial role in host defense against microbial infection. The
microbial ligands recognized by TLRs are not unique to pathogens, however, and are …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and
ulcerative colitis (UC), involves the interaction between environmental factors in the …

Systemic and local inflammation in relation to the resident microbiota of the human gastro-
intestinal (GI) tract and administration of probiotics are the main themes of the present …