Evidence has been accumulating that, in men, some of the biological actions traditionally
attributed to testosterone acting via the androgen receptor may in fact be dependent on its …

Bone and muscle are required for mobility but they also have endocrine and metabolic
functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy …

Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …

Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Context The lack of sensitive and robust analytical methods has hindered the reliable
quantification of estrogen metabolites in subjects with low concentrations. Objective To …

Context Estradiol is the primary female sex hormone and plays an important role for skeletal
health in both sexes. Several enzymes are involved in estradiol metabolism, but few …

Background: The risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased in
postmenopausal women compared with men of similar age, suggesting a role for sex …

The substantial increase in life expectancy of men has focused growing attention on quality-
of-life issues associated with reproductive aging. Serum total and free testosterone levels in …

The severe form of COVID-19 has significant sex disparities, with high fatalities commonly
reported among males than females. The incidence of COVID-19 has also been higher in …

Osteoporosis does not only affect postmenopausal women, but also ageing men. The
burden of disease is projected to increase with higher life expectancy both in females and …