Mitochondrial regulation during male germ cell development

X Wang, L Yin, Y Wen, S Yuan - Cellular and Molecular Life Sciences, 2022 - Springer
Mitochondria tailor their morphology to execute their specialized functions in different cell
types and/or different environments. During spermatogenesis, mitochondria undergo …

Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature

J Wang, W Wang, L Shen, A Zheng, Q Meng, H Li… - Frontiers in …, 2022 - frontiersin.org
Sperm carries male genetic information, and flagella help move the sperm to reach oocytes.
When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte …

Bi-allelic loss-of-function variants in CFAP58 cause flagellar axoneme and mitochondrial sheath defects and asthenoteratozoospermia in humans and mice

X He, C Liu, X Yang, M Lv, X Ni, Q Li, H Cheng… - The American Journal of …, 2020 - cell.com
Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form of
asthenoteratozoospermia. Although recent studies have revealed several MMAF-associated …

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

J Muroňová, ZE Kherraf, E Giordani, E Lambert… - Elife, 2024 - elifesciences.org
From a cohort of 167 infertile patients suffering from multiple morphological abnormalities of
the flagellum (MMAF), pathogenic bi-allelic mutations were identified in the CCDC146 gene …

Morphological Observation and Transcriptome Analysis of Ciliogenesis in Urechis unicinctus (Annelida, Echiura)

D Kong, M Wei, D Liu, Z Zhang, Y Ma… - International Journal of …, 2023 - mdpi.com
During the early development of marine invertebrates, planktic larvae usually occur, and
their body surfaces often form specific types of cilia that are involved in locomotion and …

The functionally unannotated proteome of human male tissues: a shared resource to uncover new protein functions associated with reproductive biology

Y Vandenbrouck, C Pineau, L Lane - Journal of proteome …, 2020 - ACS Publications
In the context of the Human Proteome Project, we built an inventory of 412 functionally
unannotated human proteins for which experimental evidence at the protein level exists …

Biallelic mutations of CFAP58 are associated with multiple morphological abnormalities of the sperm flagella

Y Sha, Y Sha, W Liu, X Zhu, M Weng, X Zhang… - Clinical …, 2021 - Wiley Online Library
Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe type of
teratozoospermia. In this study, whole‐exome sequencing was conducted on 55 patients …

Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications

WS Liu, BS Wu, L Yang, SD Chen, YR Zhang, YT Deng… - GeroScience, 2024 - Springer
Telomere length is a putative biomarker of aging and is associated with multiple age-related
diseases. There are limited data on the landscape of rare genetic variations in telomere …

CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice

X Wei, X Wang, C Yang, Y Gao, Y Zhang… - …, 2024 - journals.biologists.com
ABSTRACT CFAP58 is a testis-enriched gene that plays an important role in the sperm
flagellogenesis of humans and mice. However, the effect of CFAP58 on bull semen quality …

Hypo-Expression of Tuberin Promotes Adenomyosis via the mTOR1-Autophagy Axis

NH Gu, GJ Li, BX Yang, M You, Y Lin… - Frontiers in cell and …, 2021 - frontiersin.org
Adenomyosis (AM) is a disease in which endometrial tissue invades the myometrium and
has a 10–60% prevalence in reproductive-aged women. TSC2 regulates autophagy via …