An overview of influenza A virus genes, protein functions, and replication cycle highlighting important updates

RP Chauhan, ML Gordon - Virus Genes, 2022 - Springer
The recent research findings on influenza A virus (IAV) genome biology prompted us to
present a comprehensive overview of IAV genes, protein functions, and replication cycle …

Structural investigations of interactions between the influenza a virus NS1 and host cellular proteins

ME Blake, AB Kleinpeter, AS Jureka, CM Petit - Viruses, 2023 - mdpi.com
The Influenza A virus is a continuous threat to public health that causes yearly epidemics
with the ever-present threat of the virus becoming the next pandemic. Due to increasing …

Suppressing nonspecific binding in biolayer interferometry experiments for weak ligand–analyte interactions

A Dubrow, B Zuniga, E Topo, JH Cho - ACS omega, 2022 - ACS Publications
Quantitative analysis of protein–protein interactions (PPIs) using biolayer interferometry
(BLI) requires effective suppression of nonspecific binding (NSB) between analytes and …

Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus

I Kim, A Dubrow, B Zuniga, B Zhao, N Sherer… - Nature …, 2022 - nature.com
Elucidating how individual mutations affect the protein energy landscape is crucial for
understanding how proteins evolve. However, predicting mutational effects remains …

Theory and computation of nuclear shielding

T Kupka - 2020 - books.rsc.org
A review of the literature published from January to December 2019 on theoretical aspects
of nuclear magnetic shielding is presented. It covers both non-relativistic and relativistic …

[HTML][HTML] NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rationale reveals new putative druggable hot spots with an important role on viral …

J Trigueiro-Louro, LA Santos, F Almeida, V Correia… - Virology, 2022 - Elsevier
Influenza NS1 is a promising anti-influenza target, considering its conserved and druggable
structure, and key function in influenza replication and pathogenesis. Notwithstanding, target …

Targeting the Ubiquitin Proteasome System to Combat Influenza A Virus: Hijacking the Cleanup Crew

V Anang, L Antonescu, R Nho, S Soni… - Reviews in Medical …, 2024 - Wiley Online Library
Influenza A virus (IAV) remains a significant global public health threat, causing substantial
illness and economic burden. Despite existing antiviral drugs, the emergence of resistant …

RNA N6-methyladenosine methylation in influenza A virus infection

X Liu, W Chen, K Li, J Sheng - Frontiers in Microbiology, 2024 - frontiersin.org
Influenza A virus (IAV) is a negative-sense single-stranded RNA virus that causes acute lung
injury and acute respiratory distress syndrome, posing a serious threat to both animal and …

Influenza A virus–host specificity: an ongoing cross-talk between viral and host factors

M Zhang, M Liu, S Bai, C Zhao, Z Li, J Xu… - Frontiers in …, 2021 - frontiersin.org
One big threat from influenza A viruses (IAVs) is that novel viruses emerge from mutation
alongside reassortment. Some of them have gained the capability to transmit into human …

Influenza A virus NS1 protein represses antiviral immune response by hijacking NF-κB to mediate transcription of type III IFN

MC Lee, CP Yu, XH Chen, MT Liu, JR Yang… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Non-structural protein 1 (NS1), one of the viral proteins of influenza A viruses
(IAVs), plays a crucial role in evading host antiviral immune response. It is known that the …