Artificial intelligence-based toxicity prediction of environmental chemicals: future directions for chemical management applications
Recently, research on the development of artificial intelligence (AI)-based computational
toxicology models that predict toxicity without the use of animal testing has emerged …
toxicology models that predict toxicity without the use of animal testing has emerged …
The Tox21 robotic platform for the assessment of environmental chemicals–from vision to reality
MS Attene-Ramos, N Miller, R Huang, S Michael… - Drug discovery today, 2013 - Elsevier
Highlights•The Tox21 effort is to advance in vitro toxicological testing in the 21st
century.•Tox21 chemical library contains approximately 10,000 environmental chemicals.•A …
century.•Tox21 chemical library contains approximately 10,000 environmental chemicals.•A …
Non-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case study
LN Vandenberg - Dose-response, 2014 - journals.sagepub.com
Non-monotonic dose response curves (NMDRCs) have been demonstrated for natural
hormones and endocrine disrupting chemicals (EDCs) in a variety of biological systems …
hormones and endocrine disrupting chemicals (EDCs) in a variety of biological systems …
Three-dimensional cell culturing by magnetic levitation
WL Haisler, DM Timm, JA Gage, H Tseng, TC Killian… - Nature protocols, 2013 - nature.com
Recently, biomedical research has moved toward cell culture in three dimensions to better
recapitulate native cellular environments. This protocol describes one method for 3D culture …
recapitulate native cellular environments. This protocol describes one method for 3D culture …
A spheroid toxicity assay using magnetic 3D bioprinting and real-time mobile device-based imaging
An ongoing challenge in biomedical research is the search for simple, yet robust assays
using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel …
using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel …
[HTML][HTML] Estimate ecotoxicity characterization factors for chemicals in life cycle assessment using machine learning models
In life cycle assessment, characterization factors are used to convert the amount of the
chemicals and other pollutants generated in a product's life cycle to the standard unit of an …
chemicals and other pollutants generated in a product's life cycle to the standard unit of an …
In vitro platforms for evaluating liver toxicity
SS Bale, L Vernetti, N Senutovitch… - Experimental …, 2014 - journals.sagepub.com
The liver is a heterogeneous organ with many vital functions, including metabolism of
pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology …
pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology …
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Tests with vertebrates are an integral part of environmental hazard identification and risk
assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed …
assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed …
Ethinyl estradiol and other human pharmaceutical estrogens in the aquatic environment: a review of recent risk assessment data
JP Laurenson, RA Bloom, S Page, N Sadrieh - The AAPS journal, 2014 - Springer
Interest in pharmaceuticals in the environment has increased substantially in recent years.
Several studies in particular have assessed human and ecological risks from human …
Several studies in particular have assessed human and ecological risks from human …
A quantitative approach to screen for nephrotoxic compounds in vitro
Nephrotoxicity due to drugs and environmental chemicals accounts for significant patient
mortality and morbidity, but there is no high throughput in vitro method for predictive …
mortality and morbidity, but there is no high throughput in vitro method for predictive …