The lung surface of air‐breathing vertebrates is formed by a continuous epithelium that is
covered by a fluid layer. In the airways, this epithelium is largely pseudostratified consisting …

Maintenance of normal epithelial ion and water transport in the lungs includes providing a
thin layer of surface liquid that coats the conducting airways. This airway surface liquid is …

Active ion transport by basolateral Na-K-ATPase (Na pump) creates an Na+ gradient that
drives fluid absorption across lung alveolar epithelium. The α1 and β1 subunits are the most …

Background Acute respiratory distress syndrome (ARDS) is a complex clinical diagnosis
with various possible etiologies. One common feature, however, is pulmonary permeability …

Olfactory receptors (ORs) are almost ubiquitously expressed in the human body. However,
information about their functions in these tissues is lacking. To date, no functional …

Lungs contain a particular amount of fluid that is crucial for proper lung function. This fluid
content is tightly controlled within certain limits. Fluid accumulation in the alveolar airspace …

BACKGROUND AND PURPOSE The transepithelial absorption of Na+ in the lungs is crucial
for the maintenance of the volume and composition of epithelial lining fluid. The regulation of …

In pulmonary epithelia, β-adrenergic agonists regulate the membrane abundance of the
epithelial sodium channel (ENaC) and, thereby, control the rate of transepithelial electrolyte …

Tight control of lung liquid (LL) regulation is vital for pulmonary function. The aim of this work
was to determine whether PKC activation is involved in the physiological regulation of LL …

Ion channels that are principally activated by direct binding of intracellular cyclic nucleotides
have evolved as cation nonselective transducers for intracellular pathways that regulate …