The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …

Neoadjuvant checkpoint inhibition, in which the therapy is administered before surgery, is a
promising new approach to managing bulky but resectable melanoma, and is also being …

Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of
psychedelics that is closely related to an established synthetic hallucinogen, 2, 5-dimethoxy …

Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative
to traditional drug discovery processes involving de novo synthesis. Drugs that are currently …

The molecular mechanisms and pathways enabling certain individuals to remain cognitively
normal despite high levels of Alzheimer's disease (AD) pathology remain incompletely …

Current gaps in drug safety sciences can result from the inability (1) to identify hazard across
multiple target organs,(2) to predict and risk assess with certainty against drug safety …

Tauopathies are a group of neurodegenerative disorders characterized by the aggregation
of the microtubule-associated protein tau. Aggregates of misfolded tau protein are believed …

Chronic pain is a leading cause of disability worldwide and its prevalence is likely to
increase over the next decades. Treatment for chronic pain remains insufficient and …

Gait and balance abnormalities develop commonly in Parkinson's disease and are among
the motor symptoms most disabling and refractory to dopaminergic or other treatments …