Lipid metabolism in sarcopenia

A Al Saedi, DA Debruin, A Hayes, M Hamrick - Bone, 2022 - Elsevier
Sarcopenia is an age-related disease associated with loss of muscle mass and strength.
This geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and …

Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise

AM Lundsgaard, AM Fritzen, B Kiens - Trends in Endocrinology & …, 2018 - cell.com
This review summarizes how fatty acid (FA) oxidation is regulated in skeletal muscle during
exercise. From the available evidence it seems that acetyl-CoA availability in the …

Muscle lipid metabolism: role of lipid droplets and perilipins

PE Morales, JL Bucarey… - Journal of diabetes …, 2017 - Wiley Online Library
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …

The perilipins: major cytosolic lipid droplet–associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis

AR Kimmel, C Sztalryd - Annual review of nutrition, 2016 - annualreviews.org
The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …

Adipose triglyceride lipase regulation: an overview

IK Cerk, L Wechselberger… - Current Protein and …, 2018 - ingentaconnect.com
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from
triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy …

Exercise metabolism: fuels for the fire

M Hargreaves, LL Spriet - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
During exercise, the supply of adenosine triphosphate (ATP) is essential for the energy-
dependent processes that underpin ongoing contractile activity. These pathways involve …

Lipid Droplets, Phospholipase A2, Arachidonic Acid, and Atherosclerosis

MA Bermúdez, MA Balboa, J Balsinde - Biomedicines, 2021 - mdpi.com
Lipid droplets, classically regarded as static storage organelles, are currently considered as
dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and …

Luteinizing hormone regulation of inter-organelle communication and fate of the corpus luteum

E Przygrodzka, MR Plewes, JS Davis - International journal of molecular …, 2021 - mdpi.com
The corpus luteum is an endocrine gland that synthesizes the steroid hormone
progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates …

Plin5 bidirectionally regulates lipid metabolism in oxidative tissues

X Zhang, W Xu, R Xu, Z Wang, X Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Cytoplasmic lipid droplets (LDs) can store neutral lipids as an energy source when needed
and also regulate the key metabolic processes of intracellular lipid accumulation, which is …

The size matters: regulation of lipid storage by lipid droplet dynamics

J Yu, P Li - Science China Life Sciences, 2017 - Springer
Adequate energy storage is essential for sustaining healthy life. Lipid droplet (LD) is the
subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids …