Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …

Currently, stem cell donor registries include more than 35 million potential donors worldwide
to provide HLA‐matched stem cell products for patients in need of an unrelated donor …

Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5
(CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) …

The T-cell immune response is a major determinant of effective SARS-CoV-2 clearance.
Here, using the recently developed T-CoV bioinformatics pipeline (https://t-cov. hse. ru) we …

The highly polymorphic classical human leukocyte antigen (HLA) genes display strong
linkage disequilibrium (LD) that results in conserved multi-locus haplotypes. For unrelated …

HLA genes can exhibit extensive variations in frequency, especially in highly admixed
populations, such as that of Brazil. In this study, we demonstrated NGS‐based HLA typing in …

Next-generation sequencing (NGS) at the HLA-A,-B,-C,-DPA1,-DPB1,-DQA1,-DQB1,-DRB1
and-DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major …

Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed
worldwide to treat blood cancer and other life-threatening blood disorders. As successful …

Patients in need of hematopoietic stem cell transplantation often rely on unrelated stem cell
donors matched in certain human leukocyte antigen (HLA) genes. Donor search is …

The human leukocyte antigen (HLA) system, or the human version of the major
histocompatibility complex (MHC), is known for its extreme polymorphic nature and high …