Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large
amount of time and resources with largely negative results. Repurposing drugs already …

Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …

Abstract Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its
role in regulating transcription of DNA-damage response (DDR) genes. However …

Triggers of innate immune signaling in the CNS of patients with amyotrophic lateral sclerosis
and frontotemporal degeneration (ALS/FTD) remain elusive. We report the presence of …

Ischemic stroke is a major cause of mortality and disability worldwide, with limited treatment
options available in clinical practice. The emergence of stem cell therapy has provided new …

The use of human neural stem cells (hNSCs) for clinical cell therapies is limited by the lack
of effective culture substrates to produce hNSCs. Animal-sourced substrates could result in …

Cell therapies represent a promising approach to slow down the progression of currently
untreatable neurodegenerative diseases (eg, Alzheimer's and Parkinson's disease or …

Cellular differentiation requires dramatic changes in chromatin organization, transcriptional
regulation, and protein production. To understand the regulatory connections between these …

Abstract Background Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which
has been reported to improve cognitive function and memory in patients with dementia. As …

Synaptic plasticity processes, which underlie learning and memory formation, require RNA
to be translated local to synapses. The synaptic tagging hypothesis has previously been …