The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …

Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …

The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

The skeleton is an efficient'servo'(feedback-controlled/steady-state) system that continuously
integrates signals and responses which sustain its functions of delivering calcium while …

Bone is a dynamic tissue that is constantly renewed. The cell populations that participate in
this process—the osteoblasts and osteoclasts—are derived from different progenitor pools …

Abstract Runx2, osterix, and β‐catenin are essential for osteoblast differentiation. Runx2
directs multipotent mesenchymal cells to an osteoblastic lineage, and inhibits them from …

The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …

Skeletal homeostasis is determined by systemic hormones and local factors. Bone
morphogenetic proteins (BMP) are unique because they induce the differentiation of …

All mammalian uteri contain glands in the endometrium that develop only or primarily after
birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated …

The identification of ultraconserved noncoding sequences in vertebrates has been
associated with developmental regulators and DNA-binding proteins. One of the first of …