Virus-like particles in vaccine development

A Roldão, MCM Mellado, LR Castilho… - Expert review of …, 2010 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Dengue in india

N Gupta, S Srivastava, A Jain… - Indian Journal of …, 2012 - journals.lww.com
Dengue virus belongs to family Flaviviridae, having four serotypes that spread by the bite of
infected Aedes mosquitoes. It causes a wide spectrum of illness from mild asymptomatic …

Bioengineering virus‐like particles as vaccines

LHL Lua, NK Connors, F Sainsbury… - Biotechnology and …, 2014 - Wiley Online Library
Virus‐like particle (VLP) technology seeks to harness the optimally tuned immunostimulatory
properties of natural viruses while omitting the infectious trait. VLPs that assemble from a …

Virus-like particles: passport to immune recognition

EVL Grgacic, DA Anderson - Methods, 2006 - Elsevier
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid
proteins from many viruses. In many cases such VLPs have structural characteristics and …

Yeast-based vaccines: New perspective in vaccine development and application

R Kumar, P Kumar - FEMS yeast Research, 2019 - academic.oup.com
In presently licensed vaccines, killed or attenuated organisms act as a source of
immunogens except for peptide-based vaccines. These conventional vaccines required a …

Viral nanoparticles and virus‐like particles: platforms for contemporary vaccine design

EM Plummer, M Manchester - Wiley Interdisciplinary Reviews …, 2011 - Wiley Online Library
Current vaccines that provide protection against infectious diseases have primarily relied on
attenuated or inactivated pathogens. Virus‐like particles (VLPs), comprised of capsid …

Manufacturing of recombinant therapeutic proteins in microbial systems

K Graumann, A Premstaller - … Journal: Healthcare Nutrition …, 2006 - Wiley Online Library
Recombinant therapeutic proteins have gained enormous importance for clinical
applications. The first recombinant products have been produced in E. coli more than 20 …

Yeast-based virus-like particles as an emerging platform for vaccine development and delivery

V Srivastava, KN Nand, A Ahmad, R Kumar - Vaccines, 2023 - mdpi.com
Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

Next generation dengue vaccines: a review of candidates in preclinical development

J Schmitz, J Roehrig, A Barrett, J Hombach - Vaccine, 2011 - Elsevier
Dengue represents a major public health problem of growing global importance. In the
absence of specific dengue therapeutics, strategies for disease control have increasingly …

Developments in virus-like particle-based vaccines for infectious diseases and cancer

L Buonaguro, M Tagliamonte… - Expert review of …, 2011 - Taylor & Francis
Virus-like particles hold great promise for the development of effective and affordable
vaccines. Indeed, virus-like particles are suitable for presentation and efficient delivery of …