Natriuretic peptides are a family of structurally related but genetically distinct
hormones/paracrine factors that regulate blood volume, blood pressure, ventricular …

The gas NO is a messenger that modulates neuronal function. The use of NO donors and
NO synthase inhibitors as pharmacological tools revealed that this free radical is probably …

Endothelial dysfunction in the setting of cardiovascular risk factors such as
hypercholesterolemia, diabetes mellitus, chronic smoking, as well hypertension, is, at least …

Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an
important role in the maintenance of cardiovascular homeostasis. It is currently accepted that …

Our previous studies have demonstrated that natriuretic peptides (NPs), peptide hormones
with natriuretic, diuretic, and vasodilating properties, exert a potent control on the lipolysis in …

In addition to its cGMP‐selective catalytic site, cGMP‐binding cGMP‐specific
phosphodiesterase (PDE5) contains two allosteric cGMP‐binding sites and at least one …

Cyclic AMP (cAMP) and cyclic GMP (cGMP) are key second messengers involved in a
multitude of cellular events. From the wealth of synthetic analogs of cAMP and cGMP, only a …

Studies with cGMP-dependent protein kinase I (cGK-I)-deficient human cells and mice
demonstrated that cGK-I ablation completely disrupts the NO/cGMP pathway in vascular …

The molecular basis for cerebellar plasticity and motor learning remains controversial.
Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein …

The activation of protein kinase G (PKG) by cyclic guanosine 3, 5‐monophosphate (cGMP)
has become of considerable interest as a novel molecular approach for the induction of …