Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

NETosis is a regulated form of neutrophil cell death that contributes to the host defense
against pathogens and was linked to various diseases soon after its first description in 2004 …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Objective This study aimed to elucidate the presence, antigen specificities, and potential
clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a …

The interaction between neutrophils and activation of alternative complement pathway plays
a pivotal role in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated …

Neutrophils deposit antimicrobial proteins, such as myeloperoxidase and proteases on
chromatin, which they release as neutrophil extracellular traps (NETs). Neutrophils also …

Thrombotic microangiopathy (TMA) is a rare but severe disorder characterized by
endothelial cell activation and thrombus formation. It manifests with the triad of hemolytic …

Background Anti-neutrophil cytoplasmic antibodies (ANCA) are found in pauci-immune
necrotizing crescentic glomerulonephritis. In the past, the role of complement in ANCA …